Mercedes offers the sedan with either a 429-hp turbocharged 3.0-liter inline-six-cylinder engine on the S500 or a 496-hp twin-turbo 4.0-liter V-8 on the S580. Both powertrains are supplemented by a 48-volt hybrid system (called EQ Boost) and pair with a nine-speed automatic transmission and 4Matic all-wheel drive.